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Studies revealed that Akkermansia muciniphila is inversely associated with obesity, diabetes and metabolic syndrome, with higher abundance observed in healthy individuals.
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Akkermansia: Named for microbiologist Antoon Akkermans
Muciniphila: "Mucin-feeding" in Latin
Abundance & Distribution:
It accounts for approximately 1% to 5% of the total gut microbiota. The distribution of Akkermansia extends far beyond mammals, with traces found in a wide range of other animal species.
Colonization & Age Relationship:
Its colonization in the human gut begins in early childhood, and its abundance is closely correlated with age.
Discovery & Identification:
The strain was first isolated and identified in 2004 by Muriel Derrien and Willem de Vos at Wageningen University in the Netherlands.
Studies revealed that Akkermansia muciniphila is inversely associated with obesity, diabetes and metabolic syndrome, with higher abundance observed in healthy individuals.
FAHBZ39, 26-year-old female, from Bozhou, Anhui.
GDMCC No: 65707
A milestone in industrialization; the EU authorized its pasteurized form as a Novel Food.
Launch of the world’s first commercial AKK ingredient – AKK AH39.
Canada approved AKK under its Natural Health Product (NHP) framework.
Awarded FDA sGRAS certification
Became China’s first strain to complete an international human RCT clinical trial
Acts directly on the intestinal mucus layer to build the first line of defense for a healthy gut
▶ Promotes the production of intestinal mucus
▶ Enhances the expression of tight junction proteins
▶ Reduces the risk of intestinal permeability (“leaky gut”)
Addresses chronic disease risks at the source
▶ Reduces chronic low-grade inflammation
▶ Modulates immune balance
▶ Improves metabolic inflammatory environment
Supports blood glucose and weight management
▶ Improves glucose metabolism
▶ Enhances insulin sensitivity
▶ Inhibits fat accumulation
Human RCT clinical trial IRCT20230522058257N1
Duration: 8 weeks
Dosage: 10B TFU per day
◆ Waist circumference reduced by 4.27 cm (P = 0.003)
◆ Waist-to-height ratio improved (P = 0.004)
◆ Body fat percentage decreased (P = 0.032)
◆ Aspartate aminotransferase levels lowered (P = 0.045)
◆ Appetite scores reduced (P = 0.047)
HelpGut®-GLP-1 – Globally Unique Formula
◆ Akkermansia muciniphila AH39
◆ Lactobacillus casei CCFM419
◆ Bifidobacterium longum CCFM760
◆ Clostridium butyricum CCFM1299
◆ Lactobacillus plantarum CCFM1143
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