EN
- Bifidobacterium breve CCFM1025
- Lactobacillus plantarum CCFM1050
- Lactobacillus gasseri CCFM1201
- Lactobacillus casei CN1566
- Lactobacillus fermentum CCFM1126
- Pediococcus acidilactici CCFM6432
- Bifidobacterium longum CCFM760
- 1) Helps relieve menopause-related discomfort such as mood swings, stress, and emotional fluctuations
- 2) Supports bone density maintenance and skeletal health during menopause
- 3) Promotes vaginal and gut microbiota balance for feminine comfort and protection
- 4) Supports digestive regularity and gut comfort during hormonal transition
- 5) Helps support overall vitality and metabolic balance in midlife women
HelpHer™ Women Health - Improve Menopausal Symptom
Formulation
Functionality
Scientific Support
Human clinical trial
1) Zhao Y, Wang L, Zhang H, Tian P, Chen Y, Lee DS. Inhibitory effect of Lactobacillus gasseri CCFM1201 on Gardnerella vaginalis in mice with bacterial vaginosis. Arch Microbiol. 2022;204(6):315-324. doi:10.1007/s00203-022-02896-9. PMID: 35546374.
2) Tian P, Chen Y, Zhu H, Wang L, Qian X, Zou R, Zhao J, Zhang H, Qian L, Wang Q, Wang G, Chen W. Bifidobacterium breve CCFM1025 attenuates major depression disorder via regulating gut microbiome and tryptophan metabolism: A randomized clinical trial. Brain Behav Immun. 2022;100:233-241. doi:10.1016/j.bbi.2021.11.023.
3) Tian P, Yang H, Hang F, Wang G, Mao X, Jin X, Zhao J. Evaluation of the clinical efficacy of Pediococcus acidilactici CCFM6432 in alleviating depression. Microbiome Res Rep. 2024;3(4):49. doi:10.20517/mrr.2024.33. PMID: 39741947.
Pre-clinical paper
1) Li DX, Wang Y, Zhao H, et al. Efficacy of Pediococcus acidilactici CCFM6432 in alleviating symptoms of major depressive disorder (MDD) and gut microbiota alterations: evidence from an animal model. J Transl Med. 2025;23:xxx–xxx. doi:10.1186/s12967-025-xxxx-x. PMID: 40740438. PMCID: PMC12305138.
2) Tian P, O’Riordan KJ, Lee Y-K, Wang G, Zhao J, Zhang H, Cryan JF, Chen W. Towards a psychobiotic therapy for depression: Bifidobacterium breve CCFM1025 reverses chronic stress-induced depressive symptoms and gut microbial abnormalities in mice. Neurobiol Stress. 2020;12:100216. doi:10.1016/j.ynstr.2020.100216. PMID: 32258258. PMCID: PMC7109524.
Patent
1) Jiangnan University, A Bifidobacterium breve CCFM1025 strain, its fermented food and its application. Chinese Invention Patent, Granted Publication Number CN108949640B.
2) Jiangnan University, A Lactobacillus gasseri CCFM1201 strain capable of relieving bacterial vaginitis and maintaining vaginal health. Chinese Invention Patent, Granted Publication Number CN114250186B.
3) Jiangnan University, A Lactobacillus fermentum CCFM1126 strain and its application for alleviating osteoporosis. Chinese Invention Patent, Publication Number CN111718873A.
4) Jiangnan University, A Pediococcus acidilactici CCFM6432 strain for alleviating depression, food fermented thereby and application thereof. U.S. Patent, Granted Publication Number US12419918B2.
5) Wuxi Special Food and Nutrition Health Research Institute / Jiangnan University, A Bifidobacterium longum CCFM760 strain and its application. Chinese Invention Patent, Granted Publication Number CN107893044B.